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Genetic correlates of long age
There have been sparce tests of genome-wide associations between gene expression and longevity in humans, but more are coming up the pipeline. Kerber et al (2009) used a dataset of Utah grandmothers to...
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Variability to apoptotic response mediated by functional protein levels
When aptosis is induced in cell populations with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), there is a surprising amount of variation in both how long it takes for cells to die...
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Tau protein as cerebrospinal fluid markers in Alzheimer’s Disease
Buckhave et al have some interesting results from a longitudinal study of 119 patients with AD. At baseline, CSF levels of the microtubule-associated tau protein was significantly higher in both AD...
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Beta amyloid precursor promotes synaptogenesis
Amyloid precursor protein (APP) is heavily implicated in the progression of Alzheimer’s disease. When proteolytically processed they yield 40 and 42 amino acid amyloid peptides which form the beta...
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Decline in hippocampal plasticity mediated by deficits in D-serine
Most naturally occuring amino acids in animals are of the L stereoisomerism, but D-serine is an amino acid that does have biological activity. It is known to activate NMDA receptors and induce NDMA...
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Changes in myelinated axons following juggling in diffusion tensor imaging
Scholz et al performed diffusion tensor imaging on 48 adults randomly placed in either a juggling or control group. By the end of the 6-week training each of the adults in the juggling group could...
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Synaptic pruning in the mediodorsal thalamus
More neurons are born than necessary, and synaptic pruning is the process by which neurons that have not made as many functional synaptic connections with other neurons are preferentially degraded....
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Proteins differentially expressed in the aging hippocampus
In their review of the “neuroproteome” associated with aging and cognitive decline, VanGuilder and Freeman discuss some of the technical approaches and findings in the field. This illustrative figure...
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Denervation of neuromuscular junctions in the extensor digitorum longus of...
How does the connection morphology of motor neuron axons and muscle fiber endplates change with age? Chai et al recently published some results addressing, in part, this question. Their study compared...
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Cerebral blood flow regulation systematically decreases after a stroke
In everyday life, your muscles, metabolism, and nervous system work together to ensure that your cerebral blood flow meets the metabolic needs of your various brain regions. So if you are trying to...
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Transplanting dopaminergic neurons into MPTP-treated monkeys improves their...
Over the last few years researchers have figured out how to transform iPS cells into dopamine-producing neurons, raising the possibility of transplanting dopaminergic cells into the brains of patients...
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Problems with the diagnosis of idiopathic normal pressure hydrocephalus
Idiopathic normal pressure hydrocephaus (NPH) is a diagnosis of occult hydrocephalus with normal CSF pressure on LP that was first described in 1965 and is often considered one of the treatable causes...
View ArticleMicroglia can last a lifetime
An important paper from Füger et al last month, in which they labelled individual microglia in mouse brains and tracked their locations over 1.5 years. Here were some of their major findings: The...
View ArticleSingle cell histone modifications seem to accumulate randomly during aging
One of the most remarkable findings in aging over the past decade is that it’s possible to track the rate of aging based on stereotyped DNA methylation changes across a diverse set of tissues. These...
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Everest regression and the effect of age in Alzheimer’s disease
A new-to-me concept is the idea of an Everest regression — “controlling for altitude, Everest is room temperature” — wherein you use a regression model to remove a critical property of an entity, and...
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Transplanting dopaminergic neurons into MPTP-treated monkeys improves their...
Over the last few years researchers have figured out how to transform iPS cells into dopamine-producing neurons, raising the possibility of transplanting dopaminergic cells into the brains of patients...
View ArticleClik here to view.
Problems with the diagnosis of idiopathic normal pressure hydrocephalus
Idiopathic normal pressure hydrocephaus (NPH) is a diagnosis of occult hydrocephalus with normal CSF pressure on LP that was first described in 1965 and is often considered one of the treatable causes...
View ArticleMicroglia can last a lifetime
An important paper from Füger et al last month, in which they labelled individual microglia in mouse brains and tracked their locations over 1.5 years. Here were some of their major findings: The...
View ArticleSingle cell histone modifications seem to accumulate randomly during aging
One of the most remarkable findings in aging over the past decade is that it’s possible to track the rate of aging based on stereotyped DNA methylation changes across a diverse set of tissues. These...
View ArticleClik here to view.
Everest regression and the effect of age in Alzheimer’s disease
A new-to-me concept is the idea of an Everest regression — “controlling for altitude, Everest is room temperature” — wherein you use a regression model to remove a critical property of an entity, and...
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